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   Fucoidan
  Chitosan Oligosaccharide

Fucoidan, a special intercellular polysaccharide, which exists in the cell wall matrix, is the unique biological activity matter in brown algae.

We extract the fucoidan from the Laminaria japonicia. The product, which is hydrosoluble heteropolysaccharide, mainly consists of sulfuric ester- Fucose, and also have little quantities of galactose, Mannose, xylose, arabinose, saccharic-aldehyded acid. So its also called algin or fucoidan & laminaran, the major effective ingredient is -L-fucose-4-sulfuric ester.

Fucoidan is an excellent raw material of  health-foods and  drug  medicine.  Because of   natural Organic sulfate radical, it has characteristic of high molecular compound containing the negative ion. Studies showed that it have many physiologically actives, such as inhibiting blood clotting, lowering the blood fats, repelling chronic renal-failure, anti-tumor, anti-virus, regenerating tissue, Suppressing gastric ulcer,    enhancing     bodies immunity, etc.Fucoidan is an immunomodulator which have immediate effects on Macrophage and T-cell,with obvious pharmacological   activities of   inhibiting  blood clotting and promoting fibrinolysis. Fucose
 or its
 degradative  offspring  can  induce cancer-cells-apoptosis,   so it  can  be  used on revulsant and anticancer-drug. The generation of Cytokines

-growth can help all kinds of cells to grow , repair the damaged tissue and an organ or tissue functions failure.Because polysaccharides has the anticoagulant effect, which vails the patient who has hyper-blood-viscosity, it can be made to drugs and health products in counteracting or preventing the thrombos It also has an efficacy against lowering cholesterol levels and blood sugar levels, can overcome side effects of normal medicine. It can be used in treatment of chronic renal failure, especially in an early phase, improving the functions of renaland enhancing creatinine clearance. It also can be used as cements and reduction additives of metallic ion. For example, It can abate the absorption of Pb by 70%.

The general pharmacology research indicated: the dose of100mg/Kg300mg/Kg medicine to doped up dog, the dog had no obviouse effects on blood pressure and. heart-electricity. 400mg/Kg800mg/Kg had no obviouse effects on Mouse nervous system. The acute toxicity test indicated that, Mouse intravenous injection LD50 is 515.339.8 mg/Kg; The little mouse fills the stomach with medicine LD50> 4g/Kg, the big mouse fills the stomach with medicine LD50> 4g /Kg.

The long-term toxicity test indicated that,By2.5,0.9,0.3g/Kg/day,filling the stomach for the big mouse obviously with the medicine for 6 months and a months and a month recovery period,hematologytargets do not have been influenced obviously, except the hemoglutination time targets, And no obvious pathological changes are discovered in the internal organs coefficient during the histo-pathology inspection. The orally dose of 60mg/Kg for 180days is the security non-toxic dosage.

     AMES showed that Fucoidan do not have sudden change effection on the gene.

Product: FUCOIDAN  
Material: Laminaria japonicia Aresch  
Characteristics:  white or light yellow powder,  pellucidly dissolved in water  
Main usage:   1material of traditional Chinese drugs used in kidney disease.
2it can be used in health-foods and drinks.  
3it can be used in cosmetic  
Standard: enterprise standard (Q/RJJK 001-2005)  
Packing: innerpackingPE bottle, 500g /bottle  
Outpacking:  paper drum (20bottle/drum) or carton (10bottle/carton)  
Preservation:  keeo away from air, light and humidity, Quality guarantee for three years  

                  Quality Standard for Fucoidan

  Item

Norm

Fucose%

15.0

Organic SO42-%

20.0

MOISTURE%

10.0

Heavy Metalspbmg/kg

20.0

Inorganic arsenicmg/kg

2.0

Total bacteria Count

1000/g

Coliform Count

30

 Pathogenic bacteria

none

Mercury (mg/Kg)

0.3

Cadmium(mg/Kg)

0.2

 

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